The motor response to verbal or painful stimulus directly correlates with the complexity of neurological function required to produce it. 
| 
 M Score 
 | 
 Response 
 | 
 Required Brain Function 
 | 
| 
 6 
 | 
 Obeys Command 
 | 
 Complex polysynaptic, bilateral hemisphere pathways involving higher brain centres 
 | 
| 
 5 
 | 
 Localises to pain 
 | 
 Unconscious response but still requires pre-motor and motor cortex to be functional 
 | 
| 
 4 
 | 
 Withdrawal from pain 
 | 
 As above but without the pre-motor areas functioning 
 | 
| 
 3 
 | 
 Flexion to pain 
 | 
 Corticospinal tract not functioning and the more primitive rubrospinal tract in the midbrain takes over 
 | 
| 
 2 
 | 
 Extension to pain 
 | 
 Loss of midbrain function reduces the motor response to vestibulospinal/reticulospinal tracts in the medulla 
 | 
| 
 1 
 | 
 No response 
 | 
 All centres and tracts including and above brain-stem non functioning 
 | 
 
This linear relationship between motor score and brain function is the reason neurosurgical centres place more onus on this part of the GCS when prognosticating or monitoring for deteriorations [1].   Conversely, the cause of changes in Eye or Voice scores can represent an array of clinical conditions aside from interruptions in brain function.