Hyperthermia is an elevated core body temperature not related to hypothalamic activity.
Many causes exist, with a common pathway of end-organ damage due to the heat-related effects of cytotoxicity and inflammation.
Heatstroke, like other conditions associated with hyperthermia requires rapid cooling to reduce the core body temperature of the patient.
Most management strategies are supportive, but hyperthermia leading to severe disease often requires admission to critical care for organ support.
