Case of the Month #45 Major Obstetric Haemorrhage - Part 1

Published 02/11/2023

What are the Causes of MOH?

  1. Antepartum  

  • Placenta praevia 
  • Placental abruption 
  • Bleeding from genital tract (cervix, vagina or vulva) 
  • Unknown 

Placenta praevia and placental abruption are the most important causes of APH. 

  1. Intrapartum  

  • Placenta Praevia 
  • Placental Abruption 
  • Uterine rupture 
  • Amniotic Fluid embolism 
  1. Postpartum - The 4 T’s 

  • Tone- uterine atony/ abnormalities of uterine contraction (the most common cause of primary PPH- 80% of cases).  

  • Tissue- retained products of conception e.g. placental tissue, or blood clots 

  • Trauma- genital tract trauma i.e. lacerations of the cervix/ vagina/ external genitalia or perineum, extensions of uterine incisions at caesarean section, uterine rupture, uterine inversion 

  • Thrombin- abnormalities of coagulation. These can be acquired in pregnancy e.g. gestational thrombocytopenia, pre-eclampsia with HELLP, sepsis, abruption, amniotic fluid embolus, existing e.g. Haemophilia A, von Willebrand disease, or due to therapeutic anticoagulation e.g. for a history of thromboembolic disease or cardiac valve replacement. 

Early risk assessment for obstetric haemorrhage of all pregnant women is essential. 

Steps to minimise the risk of MOH antenatally include-  

  • Investigation and treatment of antenatal anaemia (consider iron supplementation for Hb <110 g/l at first contact or <105 g/l at 28 weeks). 

  • Individualised PPH risk assessment of current and previous risk factors throughout the antenatal & intrapartum period. 

Risk factors for primary PPH (the most common cause of MOH) include: 

  1. Antenatal 

  • Anaemia or bleeding disorder (Hb <95 g/L, platelets < 100 x 109/L) 

  • Body Mass Index (BMI) < 18 or >35 or booking weight < 55kg 

  • > 5 previous vaginal births 

  • Previous PPH > 1000 ml 

  • Multiple pregnancy or estimated fetal weight >4.5 kg 

  • Polyhydramnios 

  • Abnormal placental implantation 

  • Known abruption or APH 

  1. Perinatal 

  • Suspicion of chorioamnionitis/ sepsis 

  • Labour augmented with syntocinon 

  • Prolonged labour 

  • Instrumental delivery 

  • Retained products of conception