IPC Manual

Published 08/06/2022

NHSEI has published a national infection prevention and control manual for England. Although there were some conflicts with a simultaneously published update of established IPC guidance, this latter document has been withdrawn such that the IPC Manual remains the definitive, national guidance on IPC.

The manual aims to make it easy for staff to apply effective infection prevention and control (IPC) precautions, reduce variation in IPC practices, help decrease the risk of healthcare associated infections, and allow harmonisation of IPC guidance between different care settings. Its remit is broad and does not relate solely to COVID-19. This is the first such manual for NHS England. It is intended to be an evidence-based resource that will be subject to updates as evidence changes,

The manual contains several important statements that have implications for current care, including evidence-based changes to the list of aerosol-generating procedures (AGPs) that are considered to be a high risk for transmission of airborne pathogens.

Aerosol-generating procedures
The list of AGPs has been revised and contracted. The document provides a ‘list of medical procedures that are considered to be aerosol generating and associated with an increased risk of respiratory transmission’:

  • awake1 bronchoscopy (including awake tracheal intubation)
  • awake1 ear, nose and throat (ENT) airway procedures that involve respiratory suctioning
  • awake1 upper gastro-intestinal endoscopy
  • dental procedures (using high speed or high frequency devices, for example ultrasonic scalers/high speed drills)
  • induction of sputum
  • respiratory tract suctioning2
  • surgery or post-mortem procedures (like high-speed cutting/drilling) likely to produce aerosol from the respiratory tract (upper or lower) or sinuses
  • tracheostomy procedures (insertion or removal).

This means the following procedures are not now considered to be AGPs:

  • manual facemask ventilation
  • tracheal intubation and extubation
  • non-Invasive ventilation – including CPAP and Bilevel (BIPAP)
  • high-flow nasal oxygenation
  • flexible bronchoscopy in an anaesthetised/paralysed patient
  • supraglottic airway insertion, use and removal.3

Although not considered in the IPC manual, there is evidence that cough, sneeze and natural exertional respiratory activities, eg talking, shouting, deep breathing, exercise and – by implication – dyspnoea, can be associated with significant aerosol generation (see references below). In the context of anaesthesia and critical care involving close or prolonged contact with a patient who may be infected with a disease that is wholly or partly spread by airborne transmission, eg SARS-CoV-2, a risk assessment is likely to conclude that personal protective equipment (PPE) that includes respiratory protective equipment (RPE) is required, and particularly if the patient is coughing, sneezing or dyspnoeic.

Personal protective equipment
Regarding RPE, the document states that ‘a filtering face piece (FFP) must be considered when a patient is admitted with a known/suspected infectious agent/disease spread wholly or partly by the airborne route’. However, although it subsequently states that the ‘RPE for healthcare workers while a patient is considered infectious’ is ‘Fluid resistant surgical mask (FRSM) for routine care and FFP3 or Hood for AGPs’ (Appendix 11a: table), we interpret the overall advice as indicating that FFP3 masks are likely to be indicated for anaesthetists and other healthcare workers when delivering care that involves being in close proximity to patients known or suspected to have COVID-19 who may emit aerosols through respiratory activities such as those listed above, and when undertaking the AGPs in the revised list above. The document stresses the importance of decisions about PPE being based on individual patient risk assessments such that, for instance, it might be reasonable for an FRSM to replace an FFP3 when caring for a COVID-19 patient whose trachea is intubated, sealed with an inflatable cuff and attached to a breathing circuit that includes filters.

Regarding eyewear, the guidance states that the ‘ocular route of transmission for pathogens spread by the droplet/airborne route while plausible lacks scientific evidence. This lack of evidence includes having very little certainty about what the incremental benefit of using eye protection routinely when using a FRSM/FFP3 respirator. Eye protection is considered to be necessary and worn if there is a risk of spraying or splashing of blood/body fluids from patient contact or procedure, and always when used with respirators during the performance of AGPs’.

Dr Jules Brown,4 Member of the AERATOR Research Group
Professor Tony Pickering,4 Member of the AERATOR Research Group
Professor Tim Cook,4  Member of the AERATOR Research Group
Professor Will Harrop-Griffiths, RCoA Vice-President


1The term ‘awake’ includes light sedation but excludes anaesthetised and sedated patients with a tracheal tube in place.

2The available evidence relating to respiratory tract suctioning is associated with ventilation. In line with a precautionary approach, open suctioning of the respiratory tract regardless of association with ventilation has been incorporated into the current (COVID-19) AGP list. It is the consensus view of the UK IPC cell that only open suctioning beyond the oro-pharynx is currently considered an AGP, that is oral/pharyngeal suctioning is not an AGP’.

3These were not in the original AGP list but are included here for clarity.

4On behalf of the AERATOR Research Team.


Adenaiye OO et al. Infectious SARS-CoV-2 in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection. Clin Infect Dis 2021: 10.1093/cid/ciab797.

Brown J et al. A quantitative evaluation of aerosol generation during tracheal intubation and extubation. Anaesth 2021;76:174–181.

Coleman KK et al. Viral Load of SARS-CoV-2 in Respiratory Aerosols Emitted by COVID-19 Patients while Breathing, Talking, and Singing. Clin Infect Dis 2021: 10.1093/cid/ciab691.

Gregson FKA et al. Identification of the source events for aerosol generation during oesophago-gastro-duodenoscopy. Gut 2022;71:871–878.

Gregson FKA et al. Comparing aerosol concentrations and particle size distributions generated by singing, speaking and breathing. Aerosol Science and Technology 2021: 10.1080/02786826.2021.1883544.

Hamilton FW et al. Aerosol emission from the respiratory tract: an analysis of aerosol generation from oxygen delivery systems. Thorax 2022;77:276–282.

Shrimpton AJ et al. Quantitative evaluation of aerosol generation during manual facemask ventilation. Anaesth 2022;77:22–27.

Shrimpton AJ et al. A quantitative evaluation of aerosol generation during supraglottic airway insertion and removal. Anaesth 2022;77:230–231.

Wilson NM et al. The effect of respiratory activity, non-invasive respiratory support and facemasks on aerosol generation and its relevance to COVID-19. Anaesth 2021;76:1465–1474.