Case of the Month #58 From River to Resus: A Severe Case of Leptospirosis

Published 27/11/2025

Overview

Keywords: Leptospirosis, Weil’s disease, jaundice, AKI, pulmonary haemorrhage, sepsis, fever.  

A 48-year-old previously well woman presented to the Emergency Department with a 7-day history of fever, myalgia, and nausea, progressing over the past 24 hours to increasing fatigue, jaundice, and oliguria. 

 

Past Medical History: 

- No known medical conditions   

- No regular or over-the-counter medications   

- Non-smoker, does not consume alcohol   

 

Social History: 

- Works as a cattle farmer 

- Active lifestyle, enjoys wild swimming in a local river.    

- No recent foreign travel   

 

Initial Assessment: 

On ICU admission:   

- Temperature: 39.4°C   

- Heart rate: 120 bpm   

- Blood pressure: 85/45 mmHg   

- Respiratory rate: 20 bpm   

- Oxygen saturations: 86% on 2L O₂ via nasal cannula   

 

Examination findings of note: 

- Chest: Clear auscultation, occasional dry cough   

- Abdomen: Soft but tender, mild hepatomegaly   

- Other: Marked jaundice, conjunctival suffusion, oliguric (5–10 ml/hr urine output)