Rapidly absorbed orally with Peak blood levels occur at 1-3 hours, and Due to the lipophilic nature if propranolol it therefore has a large volume of distribution
The pharmacological effects last much longer than the plasma half life of 3-6 hours.
Propranolol is Metabolised in the liver by hydroxylation with at least 1 metabolite having a degree of beta blocking action. The is variable urinary excretion which is extended in overdose.
Patient suddenly seized and within seconds lost cardiac output, cardiopulmonary resuscitation commenced along with management of Propranolol OD as per ToxBase
