There is a broad spectrum of presenting features in PRES. The most common are hypertension, encephalopathy, seizures, headache and visual disturbance
Suspect the diagnosis in patients with risk factors including any cause of hypertension, or endothelial dysfunction, or associated drugs
There is not one diagnostic test, however the most strongly predictive test is by demonstrating vasogenic oedema on MRI
Actively assess the differential and exclude alternative pathologies
Treatment is supportive and includes blood pressure management, therapies to reduce cerebral oedema, and treating any precipitant
Although most patients make a good recovery, some are left with long term neurological sequelae and PRES carries a 15% mortality
